Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 8/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3373577 | 0.94 | MAPK11 (0.59) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761678 | 0.87 | MAPK14 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| Isopropylamine SCHEMBL4827262 | 0.87 | MAPK11 (0.49) | MAPK11MAPK14KCNH2PTGER1 | |
| SCHEMBL4919415 | 0.85 | MAPK11 (0.49) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4828451 | 0.85 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4762891 | 0.85 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761409 | 0.83 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4865422 | 0.83 | MAPK14 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761674 | 0.82 | MAPK11 (0.51) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4830402 | 0.81 | MAPK11 (0.50) | MAPK11MAPK14KCNH2MAPK13RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |