⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14993133 | 0.78 | — | — | |
| SCHEMBL21079 | 0.75 | — | — | |
| SCHEMBL9352 | 0.72 | — | — | |
| SCHEMBL13937029 | 0.62 | — | — | |
| SCHEMBL18806904 | 0.62 | — | — | |
| SCHEMBL14788374 | 0.62 | — | — | |
| SCHEMBL12639908 | 0.62 | — | — | |
| SCHEMBL8682 | 0.62 | — | — | |
| SCHEMBL23849487 | 0.59 | — | — | |
| SCHEMBL19292 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151346-A1 | HETEROARYL FLUOROALKENES AS DGK INHIBITORS | INCYTE CORPORATION (US) | 2024-07-18 | — | — | WO | disclosed |
| US-20240217989-A1 | Heteroaryl Fluoroalkenes As DGK Inhibitors | INCYTE CORPORATION | 2024-07-04 | — | — | US | disclosed |
| WO-2024108100-A1 | HETEROARYL FLUOROALKENES AS DGK INHIBITORS | INCYTE CORPORATION (US) | 2024-05-23 | — | — | WO | disclosed |
| EP-2785381-B1 | FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| US-9139566-B2 | Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (PET) imaging for LRRK2 | GENENTECH, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| EP-2785381-A1 | FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-08 | — | — | EP | disclosed |
| US-20130156700-A1 | FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 | GENENTECH, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| WO-2013079496-A1 | FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-06 | — | — | WO | disclosed |
| EP-1545525-B1 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2010-11-10 | — | — | EP | disclosed |
| EP-1545525-A4 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-07-01 | — | — | EP | disclosed |
| US-7354935-B2 | Radiolabeled neurokinin-1 receptor antagonists | MERCK & CO. INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-20050214204-A1 | Radiolabeled neurokinin-1 receptor antagonists | MERCK SHARP & DOHME CORP. | 2005-09-29 | — | — | US | disclosed |
| EP-1545525-A2 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004029024-A2 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2004-04-08 | — | — | WO | disclosed |