Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Irbesartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 3/20 | 0.73 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.73 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | EDNRA | P25101 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.73 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.73 |
| ▸ | ACHE | P22303 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Irbesartan SCHEMBL2212239 | 0.99 | AGTR1 (0.74) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL4246 | 0.99 | AGTR1 (0.74) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL3376730 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL3098203 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL4520818 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL683789 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL2208976 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL4726034 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL4726870 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| Irbesartan SCHEMBL4725533 | 0.98 | AGTR1 (0.73) | AGTR1LTB4R2ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102309456-B | Irbesartan sodium micro composite powder and tablets and preparation method thereof | UNIV BEIJING CHEMICAL | 2013-05-01 | — | — | CN | claimed |
| CN-101248061-B | Irbesartan alkaline earth metal salt hydrate and preparation thereof | SANOFI AVENTIS | 2011-08-24 | — | — | CN | claimed |
| CN-101248061-A | Irbesartan alkaline earth metal salt hydrate and preparation thereof | SANOFI AVENTIS (FR) | 2008-08-20 | — | — | CN | claimed |
| CN-113933414-A | Method for detecting organic impurities in irbesartan amlodipine besylate composite preparation | 株洲千金药业股份有限公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-108135886-A | For the PDE4 inhibitor of nephrosis treatment | 塔科达有限责任公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-105078913-B | A kind of Irbesartan Tablets and preparation method thereof | 山东司邦得制药有限公司 | 2018-02-27 | — | — | CN | disclosed |
| CN-103191076-B | A kind of preparation method of irbesartan tablet | 吕丕平 | 2016-08-17 | — | — | CN | disclosed |
| CN-105837464-A | Sacubitril sodium crystal forms, preparation method and application thereof | 四川海思科制药有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-105294590-A | Ultrafine power of sartan drug and derivative thereof and preparation method for ultrafine powder | WUXI XINRENTANG PHARMACEUTICAL TECHNOLOGY CO LTD | 2016-02-03 | — | — | CN | disclosed |
| CN-105078913-A | Irbesartan tablet and preparation method thereof | SHANDONG SBOND PHARMACEUTICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-102309456-B | Irbesartan sodium micro composite powder and tablets and preparation method thereof | UNIV BEIJING CHEMICAL | 2013-05-01 | — | — | CN | disclosed |
| CN-102309456-B | Irbesartan sodium micro composite powder and tablets and preparation method thereof | UNIV BEIJING CHEMICAL | 2013-05-01 | — | — | CN | disclosed |
| CN-102309456-B | Irbesartan sodium micro composite powder and tablets and preparation method thereof | UNIV BEIJING CHEMICAL | 2013-05-01 | — | — | CN | disclosed |
| CN-102309456-A | Irbesartan sodium micro composite powder and tablets and preparation method thereof | UNIV BEIJING CHEMICAL | 2012-01-11 | — | — | CN | disclosed |
| CN-102309456-A | Irbesartan sodium micro composite powder and tablets and preparation method thereof | UNIV BEIJING CHEMICAL | 2012-01-11 | — | — | CN | disclosed |
| CN-101248061-B | Irbesartan alkaline earth metal salt hydrate and preparation thereof | SANOFI AVENTIS | 2011-08-24 | — | — | CN | disclosed |
| EP-2194050-A1 | A new process for the preparation of irbesartan | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2010-06-09 | — | — | EP | disclosed |
| CN-101248061-A | Irbesartan alkaline earth metal salt hydrate and preparation thereof | SANOFI AVENTIS (FR) | 2008-08-20 | — | — | CN | disclosed |
| WO-2008018843-A1 | PROCESS FOR PRODUCING USEFUL SALTS FORM OF BIPHENYL-TETRAZOLE COMPOUNDS | ULKAR KIMYA SANAYI VE TICARET AS (TR) | 2008-02-14 | — | — | WO | disclosed |