Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 9/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072090 | 0.91 | ACKR3 (0.41) | ACKR3CNR2TP53MAPTLMNA | |
| SCHEMBL1550470 | 0.91 | ACKR3 (0.52) | ACKR3CNR2TP53MAPTLMNA | |
| SCHEMBL1073967 | 0.89 | ACKR3 (0.40) | ACKR3CNR2TP53MAPTLMNA | |
| SCHEMBL1083483 | 0.89 | ACKR3 (0.40) | ACKR3CNR2TP53MAPTLMNA | |
| SCHEMBL1549327 | 0.87 | MAPT (0.36) | ACKR3TP53MAPTPOLB | |
| SCHEMBL1074328 | 0.84 | ACKR3 (0.41) | ACKR3TP53MAPTLMNAPOLB | |
| SCHEMBL1074526 | 0.82 | MAPT (0.46) | CNR2TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1549324 | 0.82 | CNR2 (0.43) | ACKR3CNR2TP53MAPTLMNA | |
| SCHEMBL1549851 | 0.81 | CNR2 (0.40) | CNR2TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL1549941 | 0.80 | ACKR3 (0.43) | ACKR3TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B1 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2010-11-03 | — | — | EP | disclosed |
| US-7557213-B2 | Substituted quinolones and methods of use | CHEMOCENTRYX, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070167443-A1 | Substituted quinolones and methods of use | CHEMOCENTRYX, INC. (US) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167443-A1 | Substituted quinolones and methods of use | TOP2A, NQO2, TOP2B | ACKR3 3624/4885CNR2 2729/4885TP53 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.