Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | STAT3 | P40763 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3312875 | 0.85 | JAK2 (0.57) | PRKCQTBK1EGFRERBB2JAK2 | |
| SCHEMBL3373616 | 0.83 | JAK2 (0.40) | EGFRJAK2JAK1TYK2STAT3 | |
| SCHEMBL3712108 | 0.82 | JAK2 (0.52) | PRKCQTBK1EGFRERBB2JAK2 | |
| SCHEMBL13846270 | 0.80 | PRKCQ (0.43) | PRKCQTBK1EGFRERBB2JAK2 | |
| SCHEMBL3376249 | 0.77 | JAK2 (0.39) | TBK1JAK2JAK1TYK2STAT3 | |
| SCHEMBL3304605 | 0.76 | JAK2 (0.60) | TBK1JAK2JAK1TYK2STAT3 | |
| SCHEMBL2358114 | 0.76 | JAK2 (0.70) | PRKCQTBK1JAK2JAK1TYK2 | |
| SCHEMBL2363861 | 0.71 | ABL1 (0.49) | TBK1EGFRJAK2JAK1TYK2 | |
| SCHEMBL3306155 | 0.70 | JAK2 (0.57) | TBK1JAK2JAK1TYK2STAT3 | |
| SCHEMBL2358980 | 0.70 | JAK2 (0.51) | PRKCQTBK1EGFRJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |