Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | BCR | P11274 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375492 | 0.85 | MTOR (0.48) | ABL1BCRSRCJAK2JAK1 | |
| SCHEMBL3301729 | 0.81 | JAK2 (0.54) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL3377981 | 0.79 | SYK (0.43) | ABL1BCRSRCJAK2JAK1 | |
| SCHEMBL13846245 | 0.79 | ABL1 (0.53) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL3378327 | 0.77 | NTRK1 (0.42) | ABL1BCRSRCJAK2JAK1 | |
| SCHEMBL2363857 | 0.76 | ABL1 (0.48) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL2363859 | 0.72 | ABL1 (0.48) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL2358226 | 0.71 | CCNE1 (0.57) | ABL1PRKACAJAK2JAK1TYK2 | |
| SCHEMBL3374818 | 0.71 | PRKCQ (0.43) | ABL1EGFRJAK2JAK1TYK2 | |
| SCHEMBL2356289 | 0.71 | JAK2 (0.58) | ABL1EGFRPRKACAJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349260-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |