Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912960 | 0.90 | MMP13 (0.50) | MMP13 | |
| SCHEMBL7912973 | 0.86 | MMP13 (0.59) | MMP13 | |
| SCHEMBL3378229 | 0.85 | MMP13 (0.68) | MMP13 | |
| SCHEMBL7921321 | 0.84 | MMP13 (0.64) | MMP13 | |
| SCHEMBL3372699 | 0.83 | MMP13 (0.56) | MMP13 | |
| SCHEMBL7920029 | 0.79 | MMP13 (0.61) | MMP13 | |
| SCHEMBL3379304 | 0.79 | MMP13 (0.52) | MMP13 | |
| SCHEMBL1313838 | 0.79 | MMP13 (0.64) | MMP13 | |
| SCHEMBL1316190 | 0.78 | MMP13 (0.59) | MMP13 | |
| SCHEMBL1313714 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785489-B2 | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| WO-2010045188-A1 | HETEROARYL SUBSTITUTED INDOLE COMPOUNDS USEFUL AS MMP-13 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-22 | — | — | WO | disclosed |