Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.54 |
| ▸ | GSK3B | P49841 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086192 | 0.88 | HTR3A (0.68) | HTR3AGSK3BNPC1RAB9ADYRK1A | |
| SCHEMBL2086190 | 0.88 | HTR3A (0.68) | HTR3AGSK3BNPC1RAB9ADYRK1A | |
| SCHEMBL2087070 | 0.84 | HTR3A (0.62) | HTR3AGSK3BNPC1RAB9ADYRK1A | |
| SCHEMBL2087068 | 0.84 | HTR3A (0.62) | HTR3AGSK3BNPC1RAB9ADYRK1A | |
| SCHEMBL2087378 | 0.84 | HTR3A (0.62) | HTR3AGSK3BNPC1RAB9ADYRK1A | |
| SCHEMBL2087708 | 0.81 | HTR3A (0.68) | HTR3AGSK3BDYRK1A | |
| SCHEMBL2087052 | 0.81 | HTR3A (0.68) | HTR3AGSK3BDYRK1A | |
| SCHEMBL2087354 | 0.78 | DYRK1A (0.56) | GSK3BNPC1RAB9ADYRK1AWNT1 | |
| SCHEMBL2087846 | 0.77 | DYRK1A (0.46) | GSK3BDYRK1AWNT1USP30 | |
| SCHEMBL2087377 | 0.77 | GSK3B (0.67) | HTR3AGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | claimed |