Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | CCR3 | P51677 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414223 | 0.89 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2S1PR1 | |
| SCHEMBL3380337 | 0.88 | KCNH2 (0.42) | HRH3KCNH2ALDH1A1KMT2AFFAR1 | |
| SCHEMBL3380203 | 0.88 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2S1PR1 | |
| SCHEMBL3381646 | 0.87 | HRH3 (0.49) | HRH3HRH1CCR3KCNH2S1PR1 | |
| SCHEMBL3377233 | 0.85 | HRH3 (0.49) | HRH3HRH1CCR3KCNH2ALDH1A1 | |
| SCHEMBL3377866 | 0.85 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2ALDH1A1 | |
| SCHEMBL3377635 | 0.85 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2ALDH1A1 | |
| SCHEMBL3380675 | 0.85 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2POLB | |
| SCHEMBL3378100 | 0.84 | HRH3 (0.40) | HRH3ALDH1A1POLBKMT2AFFAR1 | |
| SCHEMBL3378194 | 0.84 | HRH3 (0.47) | HRH3HRH1CCR3KCNH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |