Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381197 | 0.88 | HRH3 (0.39) | KCNH2MCHR1HRH3ADRB2MEN1 | |
| SCHEMBL3375675 | 0.88 | HRH3 (0.49) | KCNH2ALDH1A1HRH3FFAR1MEN1 | |
| SCHEMBL3377403 | 0.86 | KMT2A (0.44) | KCNH2MCHR1HRH3ADRB2MEN1 | |
| SCHEMBL3378086 | 0.85 | KCNH2 (0.44) | KCNH2MCHR1ALDH1A1HRH3ADRB2 | |
| SCHEMBL3380018 | 0.84 | ALDH1A1 (0.47) | KCNH2MCHR1ALDH1A1MEN1KMT2A | |
| SCHEMBL3378100 | 0.84 | HRH3 (0.40) | ALDH1A1HRH3FFAR1MEN1KMT2A | |
| SCHEMBL3379775 | 0.82 | KCNH2 (0.43) | KCNH2MCHR1HRH3ADRB2MEN1 | |
| SCHEMBL3377718 | 0.81 | KCNH2 (0.42) | KCNH2MCHR1HRH3ADRB2MEN1 | |
| SCHEMBL3378010 | 0.80 | HRH3 (0.49) | HRH3ADRB2MEN1KMT2A | |
| SCHEMBL3378007 | 0.80 | HRH3 (0.49) | HRH3ADRB2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |