Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008753 | 0.75 | KDM4E (0.55) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL256383 | 0.75 | KDM4E (0.55) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL21089903 | 0.75 | KDM4E (0.59) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL14895754 | 0.75 | KDM4E (0.55) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL17114770 | 0.75 | KDM4E (0.55) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL23227964 | 0.75 | KDM4E (0.55) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL22607399 | 0.71 | KDM4E (0.50) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL983824 | 0.71 | KDM4E (0.50) | KDM4EKDM4DCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9935772 | 0.71 | KDM4E (0.50) | KDM4EKDM4DHTTMMP2TSHR | |
| SCHEMBL14016377 | 0.71 | KDM4E (0.50) | KDM4EKDM4DMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2239262-A2 | Fused ring heterocycle kinase modulators | SGX Pharmaceuticals, Inc. (US) | 2010-10-13 | — | — | EP | disclosed |