Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14262719 | 0.76 | FGFR1 (0.50) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL21089903 | 0.75 | KDM4E (0.59) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL17114770 | 0.75 | KDM4E (0.55) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL14895754 | 0.75 | KDM4E (0.55) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL3375873 | 0.75 | KDM4E (0.55) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL23227964 | 0.75 | KDM4E (0.55) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL256383 | 0.75 | KDM4E (0.55) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL9935772 | 0.75 | KDM4E (0.50) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL3415322 | 0.73 | KDM4E (0.53) | KDM4EKDM4DPARP1FGFR1FGFR4 | |
| SCHEMBL31037735 | 0.73 | KDM4E (0.53) | KDM4EKDM4DPARP1FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662078-B1 | REAGENTS FOR PEPTIDE COUPLINGS | RES CORP TECHNOLOGIES INC (US) | 2003-05-02 | — | — | EP | disclosed |
| US-RE38073-E1 | Biosynthesis; using dehydration agent | RESEARCH CORPORATIONS TECHNOLOGIES, INC. | 2003-04-08 | — | — | US | disclosed |
| US-6534627-B1 | Using FMOC (9-fluorenylmethyloxycarbonyl) and tert-butyl containing compounds as protecting group; efficiency and storage stability | RESEARCH CORPORATION TECNOLOGIES, INC. | 2003-03-18 | — | — | US | disclosed |
| US-RE37686-E1 | Azahydroxybenzotriazoles and derivatives thereof for peptide coupling reactions | RESEARCH CORPORATION TECHNOLOGIES, INC. | 2002-04-30 | — | — | US | disclosed |
| US-6040422-A | REACTING A FLUOROFORMAMIDINIUM SALT WITH AN N-AMINO PROTECTED, OPTIONALLY SIDE CHAIN PROTECTED AMINO ACID; THEN REACTING PRODUCT WITH A CARBOXY PROTECTED AMINO ACID; FOR COMPOUNDS WITH LONG TERM STORAGE STABILITY | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| US-5750767-A | REACTING PROTECTED AMINO ACID WITH FLUOROFORMAMIDINIUM SALT | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5712418-A | FLUOROFORMAMIDINIUM SALTS AS FLUORINATION AGENTS TO FORM PEPTIDES | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-01-27 | — | — | US | disclosed |
| US-5698675-A | AMIDATION; ESTERIFICATION | RESEARCH CORPORATION TECH., INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5644029-A | TRIAZOLO-PYRIDINE HETEROCYCLIC COMPOUNDS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5580981-A | YELLOW INDICATORS FADING TO COLORLESS UPON COMPLETION OF THE ACYLATION STEP IN AMIDE FORMATION; REACTION ACCELERATORS; LOWERS RACEMIZATION | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1996-12-03 | — | — | US | disclosed |
| WO-1996004297-A9 | SYNTHESIS AND USE OF AMINO ACID FLUORIDES AS PEPTIDE COUPLING REAGENTS | — | 1996-05-02 | — | — | WO | disclosed |
| WO-1996004297-A1 | SYNTHESIS AND USE OF AMINO ACID FLUORIDES AS PEPTIDE COUPLING REAGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1996-02-15 | — | — | WO | disclosed |