Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CNR2 | P34972 | 8/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371521 | 0.92 | TSHR (0.64) | TSHRCNR2CYP2C19ALDH1A1MGLL | |
| SCHEMBL3373133 | 0.88 | TSHR (0.47) | TSHRCNR2CYP2C19ALDH1A1MGLL | |
| SCHEMBL23064545 | 0.86 | TSHR (0.45) | TSHRCNR2CYP2C19ALDH1A1MGLL | |
| SCHEMBL3376641 | 0.85 | TSHR (0.47) | TSHRCNR2CYP2C19ALDH1A1MGLL | |
| SCHEMBL3373701 | 0.82 | NR1H2 (0.48) | TSHRCNR2CYP2C19ALDH1A1NR1H2 | |
| SCHEMBL3376961 | 0.79 | TSHR (0.50) | TSHRCNR2CYP2C19ALDH1A1MGLL | |
| SCHEMBL3373915 | 0.77 | TSHR (0.50) | TSHRCNR2CYP2C19ALDH1A1MGLL | |
| SCHEMBL3374401 | 0.76 | TSHR (0.52) | TSHRALDH1A1LMNAAOC3KDM4E | |
| SCHEMBL4407628 | 0.75 | TSHR (0.91) | TSHRCNR2CYP2C19ALDH1A1NR1H2 | |
| SCHEMBL179996 | 0.75 | TSHR (1.00) | TSHRCNR2CYP2C19ALDH1A1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | TSHR 1622/4885CNR2 2433/4885CYP2C19 1060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.