Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377781 | 0.99 | ALDH1A1 (0.41) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3378215 | 0.94 | CYP2A13 (0.39) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3376045 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3378045 | 0.89 | KDM4E (0.40) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3377477 | 0.87 | KDM4E (0.39) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3380056 | 0.87 | CXCR4 (0.45) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3377771 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1POLBHRH3MEN1 | |
| SCHEMBL3379302 | 0.86 | CXCR4 (0.42) | KDM4EALDH1A1POLBHRH3CXCR4 | |
| SCHEMBL3377736 | 0.85 | SMN1; SMN2 (0.38) | KDM4EALDH1A1POLBHRH3CXCR4 | |
| SCHEMBL3379997 | 0.85 | CXCR4 (0.41) | KDM4EALDH1A1POLBHRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |