Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020308 | 0.93 | LMNA (0.64) | MEN1KMT2AABCC4LMNAPKM | |
| SCHEMBL1073552 | 0.84 | KMT2A (0.57) | MEN1KMT2AABCC4LMNAPKM | |
| SCHEMBL1022198 | 0.83 | TSHR (0.59) | MEN1KMT2AABCC4LMNAPKM | |
| SCHEMBL1073554 | 0.83 | MAPT (0.48) | MEN1KMT2AABCC4LMNAPKM | |
| SCHEMBL1073114 | 0.81 | ACKR3 (0.60) | ACKR3MAPTTP53RXFP1POLB | |
| SCHEMBL1022142 | 0.81 | ACKR3 (0.73) | LMNAACKR3MAPTTP53RXFP1 | |
| SCHEMBL13069024 | 0.81 | LMNA (0.64) | MEN1KMT2AABCC4LMNAPKM | |
| SCHEMBL1075564 | 0.80 | ACKR3 (0.58) | MEN1KMT2AABCC4LMNAPKM | |
| SCHEMBL1074330 | 0.77 | MAPT (0.58) | ACKR3MAPTTP53RXFP1POLB | |
| SCHEMBL1022692 | 0.75 | MEN1 (0.52) | MEN1KMT2AABCC4LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B1 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2010-11-03 | — | — | EP | disclosed |