Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064451 | 0.91 | HCRTR2 (0.38) | HCRTR2TSHRSMN1; SMN2HCRTR1GSK3B | |
| SCHEMBL2065326 | 0.90 | KMT2A (0.46) | HCRTR2TSHRHCRTR1GSK3BKDM4D | |
| SCHEMBL2064928 | 0.88 | KDM5A (0.41) | HCRTR2TSHRHCRTR1GSK3BKDM4D | |
| SCHEMBL2065962 | 0.88 | KMT2A (0.46) | HCRTR2TSHRHCRTR1GSK3BKDM4D | |
| SCHEMBL2064796 | 0.86 | CGAS (0.39) | GSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL2067036 | 0.86 | CYP2C9 (0.40) | HCRTR2HCRTR1GSK3B | |
| SCHEMBL4383616 | 0.84 | MEN1 (0.47) | ALDH1A1MEN1KMT2A | |
| SCHEMBL2066118 | 0.84 | ALDH1A1 (0.43) | HCRTR2HCRTR1GSK3BKDM4DALDH1A1 | |
| SCHEMBL2066786 | 0.83 | GSK3B (0.47) | HCRTR2HCRTR1GSK3BMEN1KMT2A | |
| SCHEMBL4952879 | 0.82 | MEN1 (0.47) | ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957492-B1 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | SANOFI AVENTIS (FR) | 2010-11-10 | — | — | EP | claimed |
| EP-1957492-A2 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | sanofi-aventis (FR) | 2008-08-20 | — | — | EP | claimed |
| WO-2007057790-A2 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2007-05-24 | — | — | WO | claimed |