Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23974192 | 0.87 | OPRL1 (0.42) | SPHK1OPRL1 | |
| SCHEMBL6179296 | 0.84 | EPHX1 (0.39) | SPHK1EPHX1NAAA | |
| SCHEMBL7718359 | 0.82 | NAAA (0.40) | SPHK1EPHX1NAAA | |
| SCHEMBL7713427 | 0.81 | NAAA (0.42) | SPHK1EPHX1NAAA | |
| SCHEMBL352809 | 0.79 | OPRL1 (0.38) | OPRL1 | |
| SCHEMBL354598 | 0.78 | OPRL1 (0.37) | OPRL1 | |
| SCHEMBL354907 | 0.78 | OPRL1 (0.37) | OPRL1 | |
| SCHEMBL24946123 | 0.77 | KDM4E (0.38) | OPRL1 | |
| SCHEMBL28524188 | 0.76 | CNR2 (0.39) | EPHX1NAAA | |
| SCHEMBL6680069 | 0.76 | EPHX1 (0.42) | SPHK1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194050-A1 | A new process for the preparation of irbesartan | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2010-06-09 | — | — | EP | disclosed |
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5541209-A | Use of irbesartan or salts thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |