Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.50 |
| ▸ | JAK1 | P23458 | 12/20 | 0.50 |
| ▸ | JAK3 | P52333 | 7/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.50 |
| ▸ | RET | P07949 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.50 |
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | LTK | P29376 | 2/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.50 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376129 | 0.99 | JAK2 (0.49) | JAK2JAK1JAK3HDAC6TYK2 | |
| Acetonitrile SCHEMBL18036542 | 0.93 | JAK2 (0.52) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL2358804 | 0.80 | JAK2 (0.49) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL13286408 | 0.80 | AURKA (0.62) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL30589328 | 0.80 | AURKA (0.62) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3375416 | 0.80 | GRM4 (0.67) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL3378527 | 0.79 | JAK1 (0.60) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3374026 | 0.79 | JAK2 (0.51) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL6126705 | 0.79 | HTR2C (0.44) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3376608 | 0.78 | JAK2 (0.49) | JAK2JAK1JAK3TYK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11957931-B2 | Compositions and methods for treating vitiligo | YALE UNIVERSITY (US) | 2024-04-16 | — | — | US | disclosed |
| US-20200069965-A1 | Compositions and Methods for Treating Vitiligo | UNIV YALE (US) | 2020-03-05 | — | — | US | disclosed |
| CN-105541847-A | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d] pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile | INCYTE CORP | 2016-05-04 | — | — | CN | disclosed |
| CN-102596960-B | Hydroxy, keto, and glucuronide derivatives of 3- (4- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile | INCYTE CORP. (US) | 2016-01-20 | — | — | CN | disclosed |
| CN-101815717-B | Metabolites of the JANUS kinase inhibitor -3- (4- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile | INCYTE CORP | 2014-06-25 | — | — | CN | disclosed |
| WO-2013173506-A2 | METHOD OF TREATING MUSCULAR DEGRADATION | RIGEL PHARMACEUTICALS, INC. (US) | 2013-11-21 | — | — | WO | disclosed |
| CN-102596960-A | Hydroxy, keto, and glucuronide derivatives of 3- (4- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile | INCYTE CORP | 2012-07-18 | — | — | CN | disclosed |
| CN-101815717-A | Metabolites of the JANUS kinase inhibitor -3- (4- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile | INCYTE CORP | 2010-08-25 | — | — | CN | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |