Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 17/20 | 0.43 |
| ▸ | JAK1 | P23458 | 11/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6127153 | 0.84 | JAK1 (0.58) | JAK2JAK1RETJAK3ROCK1 | |
| SCHEMBL6126707 | 0.82 | JAK2 (0.45) | HTR2CJAK2JAK1HDAC6DAPK3 | |
| SCHEMBL6127180 | 0.80 | JAK2 (0.45) | JAK2JAK1 | |
| SCHEMBL3377808 | 0.79 | JAK2 (0.50) | JAK2JAK1HDAC6DAPK3PAK4 | |
| SCHEMBL6126746 | 0.78 | JAK2 (0.46) | JAK2JAK1 | |
| SCHEMBL3376129 | 0.78 | JAK2 (0.49) | JAK2JAK1HDAC6DAPK3PAK4 | |
| SCHEMBL6127073 | 0.76 | JAK2 (0.49) | JAK2JAK1 | |
| SCHEMBL6127598 | 0.76 | MERTK (0.53) | JAK2JAK1 | |
| SCHEMBL6127205 | 0.76 | MERTK (0.49) | JAK2JAK1 | |
| SCHEMBL6127102 | 0.76 | MERTK (0.54) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640723-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | Incyte Corporation (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |