Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 10/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377870 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL3382371 | 0.83 | KMT2A (0.47) | CYP1A2GRM3GRM8GRM6GRIN2D | |
| SCHEMBL3382374 | 0.83 | KMT2A (0.47) | CYP1A2GRM3GRM8GRM6GRIN2D | |
| SCHEMBL3379044 | 0.82 | TET2 (0.52) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL3379045 | 0.82 | TET2 (0.52) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL3382016 | 0.82 | TET2 (0.46) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL3382012 | 0.82 | TET2 (0.46) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL3379191 | 0.78 | CHRM1 (0.50) | GRIK1SLC1A3SLC1A2SLC1A1GRIK2 | |
| SCHEMBL3379188 | 0.78 | CHRM1 (0.50) | GRIK1SLC1A3SLC1A2SLC1A1GRIK2 | |
| SCHEMBL3381888 | 0.77 | TDP1 (0.40) | FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017405-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | HELLER ADAM (US) | 2010-02-11 | — | — | WO | claimed |
| WO-2010017405-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | HELLER ADAM (US) | 2010-02-11 | — | — | WO | disclosed |