Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380675 | 0.90 | HRH3 (0.48) | HRH3KCNH2HRH1CCR3MCHR1 | |
| SCHEMBL3378194 | 0.89 | HRH3 (0.47) | HRH3KCNH2HRH1CCR3MCHR1 | |
| SCHEMBL3377526 | 0.88 | HRH3 (0.47) | HRH3LSSKCNH2HRH1CCR3 | |
| SCHEMBL3377866 | 0.85 | HRH3 (0.48) | HRH3LSSKCNH2HRH1CCR3 | |
| SCHEMBL3377732 | 0.83 | HRH3 (0.47) | HRH3LSSKCNH2HRH1CCR3 | |
| SCHEMBL3377365 | 0.83 | HRH3 (0.47) | HRH3KCNH2HRH1CCR3MCHR1 | |
| SCHEMBL3381646 | 0.83 | HRH3 (0.49) | HRH3LSSKCNH2HRH1CCR3 | |
| SCHEMBL3375675 | 0.83 | HRH3 (0.49) | HRH3KCNH2HRH1CCR3 | |
| SCHEMBL3376039 | 0.82 | HRH3 (0.47) | HRH3LSSKCNH2HRH1CCR3 | |
| SCHEMBL3380203 | 0.82 | HRH3 (0.48) | HRH3KCNH2HRH1CCR3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |