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Cyclopentane

Cyclopentane

SCHEMBL3378129

C1CCCC1.CN(CC1CC(Oc2cccc(CN3CCCC3)c2Cl)C1)C(=O)O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ HRH3 Q9Y5N1 1/20 0.46
▸ KDM4E B2RXH2 5/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ POLB P06746 1/20 0.43
▸ P2RX7 Q99572 1/20 0.41
▸ TSHR P16473 1/20 0.39
▸ BCHE P06276 1/20 0.39
▸ SIGMAR1 Q99720 1/20 0.36
▸ S1PR5 Q9H228 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyclopropane SCHEMBL3380221 1.00 MEN1 (0.47) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3379890 1.00 MEN1 (0.47) MEN1KMT2AHRH3KDM4EALDH1A1
Cyclohexane SCHEMBL3379321 1.00 MEN1 (0.47) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3378152 0.95 HRH3 (0.43) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3376004 0.91 HRH3 (0.56) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3376806 0.89 HRH3 (0.43) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3378988 0.89 HRH3 (0.45) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3376182 0.89 HRH3 (0.45) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3374844 0.88 HRH3 (0.44) MEN1KMT2AHRH3KDM4EALDH1A1
SCHEMBL3377424 0.88 HRH3 (0.44) MEN1KMT2AHRH3KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1899296-B1 HISTAMINE-3 RECEPTOR ANTAGONISTS PFIZER PROD INC (US) 2010-11-17 — — EP claimed