Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379890 | 0.95 | MEN1 (0.47) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| Cyclohexane SCHEMBL3379321 | 0.95 | MEN1 (0.47) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| Cyclopropane SCHEMBL3380221 | 0.95 | MEN1 (0.47) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| Cyclopentane SCHEMBL3378129 | 0.95 | MEN1 (0.47) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3381553 | 0.89 | MEN1 (0.43) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3376004 | 0.88 | HRH3 (0.56) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3377185 | 0.87 | HRH3 (0.43) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3376806 | 0.87 | HRH3 (0.43) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3378988 | 0.87 | HRH3 (0.45) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3376182 | 0.87 | HRH3 (0.45) | HRH3MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |