Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381212 | 0.98 | CNR2 (0.53) | CNR2RAB9APTK2CYP3A4CYP2C9 | |
| SCHEMBL3380132 | 0.91 | CNR2 (0.53) | CNR2PTK2CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3383470 | 0.86 | CNR2 (0.64) | CNR2CYP3A4CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL3381292 | 0.86 | CNR2 (0.59) | CNR2RAB9ACYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3379863 | 0.85 | CNR2 (0.63) | CNR2CYP3A4CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL3382316 | 0.85 | CNR2 (0.66) | CNR2RAB9ACYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3379589 | 0.84 | CNR2 (0.52) | CNR2PTK2CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3382862 | 0.84 | CNR2 (0.59) | CNR2PTK2CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3381376 | 0.84 | CNR2 (0.66) | CNR2CYP3A4CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL3380444 | 0.84 | CNR2 (0.65) | CNR2RAB9ACYP3A4CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878725-B1 | Pyrimidine derivatives and their use as CB2 modulators | GLAXO GROUP LTD (GB) | 2010-11-24 | — | — | EP | claimed |