Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637922 | 0.84 | ALOX15 (0.61) | ALOX15EGLN1KCNH2CXCR4HPGD | |
| SCHEMBL18325377 | 0.83 | ALOX15 (0.81) | ALOX15EGLN1KCNH2HPGDPOLB | |
| SCHEMBL807358 | 0.83 | ALOX15 (0.81) | ALOX15EGLN1KCNH2HPGDPOLB | |
| SCHEMBL4515060 | 0.81 | ALOX15 (0.85) | ALOX15EGLN1KCNH2POLBGAA | |
| SCHEMBL1953418 | 0.81 | ALOX15 (0.85) | ALOX15EGLN1KCNH2HPGDPOLB | |
| SCHEMBL15329166 | 0.81 | ALOX15 (1.00) | ALOX15EGLN1HTR1DHTR1BALDH1A1 | |
| SCHEMBL18325480 | 0.81 | ALOX15 (0.71) | ALOX15EGLN1KCNH2CXCR4HTR1D | |
| SCHEMBL4731563 | 0.75 | ALOX15 (0.79) | ALOX15EGLN1CXCR4TDP1HTR1D | |
| SCHEMBL5709857 | 0.75 | ALOX15 (0.79) | ALOX15EGLN1KCNH2HTR1DHTR1B | |
| SCHEMBL6484067 | 0.75 | ALOX15 (0.79) | ALOX15EGLN1KCNH2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557836-B2 | Spiro-piperidine inhibitors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-10-15 | — | — | US | disclosed |
| US-20100069420-A1 | SPIRO-PIPERIDINE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069420-A1 | SPIRO-PIPERIDINE INHIBITORS | HSP90B1, PSTPIP2, HAVCR2 | ALOX15 4839/4885EGLN1 1668/4885KCNH2 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.