Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379713 | 0.86 | POLB (0.36) | KDM4EALDH1A1POLBTDP1HRH3 | |
| SCHEMBL3379715 | 0.86 | POLB (0.36) | KDM4EALDH1A1POLBTDP1HRH3 | |
| SCHEMBL3376555 | 0.84 | HRH3 (0.38) | KDM4EALDH1A1POLBTDP1HRH3 | |
| SCHEMBL3376557 | 0.84 | HRH3 (0.38) | KDM4EALDH1A1POLBTDP1HRH3 | |
| SCHEMBL3442077 | 0.82 | CXCR4 (0.34) | KDM4EALDH1A1POLBTDP1HRH3 | |
| SCHEMBL3377939 | 0.80 | HRH3 (0.48) | KDM4EALDH1A1TDP1HRH3RPS6KB1 | |
| SCHEMBL3377216 | 0.79 | HRH3 (0.39) | KDM4EALDH1A1HRH3RPS6KB1CHEK1 | |
| SCHEMBL3377215 | 0.78 | HRH3 (0.34) | KDM4EALDH1A1POLBTDP1HRH3 | |
| SCHEMBL3442149 | 0.78 | HRH3 (0.52) | KDM4EALDH1A1POLBHRH3RPS6KB1 | |
| SCHEMBL3442151 | 0.78 | HRH3 (0.52) | KDM4EALDH1A1POLBHRH3RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |