Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069646 | 0.84 | CYP3A4 (0.41) | CYP3A4MAPTALDH1A1KDM4ETMEM97 | |
| SCHEMBL13070037 | 0.84 | CYP3A4 (0.41) | CYP3A4MAPTALDH1A1KDM4ETMEM97 | |
| SCHEMBL3518175 | 0.83 | NPC1 (0.41) | MAPTNPC1RAB9ATP53NPSR1 | |
| SCHEMBL1986826 | 0.80 | ALOX15 (0.44) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL10335043 | 0.80 | AKR1B1 (0.45) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| Hydrochloric Acid SCHEMBL10335958 | 0.79 | ALOX15 (0.43) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4382214 | 0.78 | CYP3A4 (0.41) | CYP3A4MAPTALDH1A1KDM4ETMEM97 | |
| SCHEMBL10334288 | 0.78 | AKR1B1 (0.40) | NPC1RAB9AHPGDCYP1A2CYP2C19 | |
| SCHEMBL3518868 | 0.77 | NPC1 (0.41) | MAPTNPC1RAB9ATP53NPSR1 | |
| SCHEMBL23618118 | 0.76 | PPARA (0.47) | CYP3A4MAPTALDH1A1KDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796665-B1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK SHARP & DOHME (US) | 2010-11-17 | — | — | EP | disclosed |
| EP-1796665-A4 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1796665-A2 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | Merck & Co., Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033891-A2 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO., INC. (US) | 2006-03-30 | — | — | WO | disclosed |