Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931666 | 1.00 | MAPT (0.50) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL6881780 | 0.89 | MAPT (0.50) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL8248506 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL13759541 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL3773115 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL8244522 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL3865686 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL337773 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL17298642 | 0.87 | MAPT (0.51) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL2013099 | 0.87 | MAPT (0.51) | MAPTMEN1KMT2AHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023885-B2 | Process for the preparation of pregabalin | HIKAL LIMITED (IN) | 2018-07-17 | — | — | US | disclosed |
| US-10023885-B2 | Process for the preparation of pregabalin | HIKAL LIMITED (IN) | 2018-07-17 | — | — | US | disclosed |
| US-20150344919-A1 | PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2015-12-03 | — | — | US | disclosed |
| EP-1841726-B1 | AN ASYMMETRIC SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | TEVA PHARMA (IL) | 2012-10-31 | — | — | EP | disclosed |
| EP-1841726-B1 | AN ASYMMETRIC SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | TEVA PHARMA (IL) | 2012-10-31 | — | — | EP | disclosed |
| US-8212071-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-07-03 | — | — | US | disclosed |
| US-8212071-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-07-03 | — | — | US | disclosed |
| US-8097754-B2 | Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-01-17 | — | — | US | disclosed |
| US-7973196-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2011-07-05 | — | — | US | disclosed |
| US-7973196-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2011-07-05 | — | — | US | disclosed |
| US-7446220-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-11-04 | — | — | US | disclosed |
| US-7446220-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-11-04 | — | — | US | disclosed |
| US-7446220-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-11-04 | — | — | US | disclosed |
| WO-2008118427-A2 | SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYL HEXANOIC ACID | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-10-02 | — | — | WO | disclosed |
| EP-1841726-A1 | AN ASYMMETRIC SYNTHESIS OF ( S ) - ( + ) -3- (AMINOMETHYL) -5-METHYLHEXANOIC ACID | Teva Pharmaceutical Industries Ltd (IL) | 2007-10-10 | — | — | EP | disclosed |
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| WO-2007035890-A1 | AN ASYMMETRIC SYNTHESIS OF ( S ) - ( + ) -3- (AMINOMETHYL) -5-METHYLHEXANOIC ACID | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035890-A1 | AN ASYMMETRIC SYNTHESIS OF ( S ) - ( + ) -3- (AMINOMETHYL) -5-METHYLHEXANOIC ACID | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | MAPT 2162/4885MEN1 3041/4885KMT2A 1689/4885 |
| US-10023885-B2 | Process for the preparation of pregabalin | CHRNA6, CHRNA9, ADH5 | MAPT 2852/4885MEN1 4583/4885KMT2A 3317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.