Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.77 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.77 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.77 |
| ▸ | PPARA | Q07869 | 3/20 | 0.69 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.67 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007408 | 1.00 | HDAC3 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7515225 | 1.00 | HDAC3 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7049246 | 0.93 | FFAR4 (0.75) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL503552 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL557510 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL25228768 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11790866 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1008297 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11616532 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL712775 | 0.89 | PPARA (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280764-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2010-11-24 | — | — | EP | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-20090130344-A1 | COMPOSITION, FILM AND LIQUID CRYSTAL DISPLAY | FUJIFILM CORPORATION (JP) | 2009-05-21 | — | — | US | disclosed |
| US-20090130344-A1 | COMPOSITION, FILM AND LIQUID CRYSTAL DISPLAY | FUJIFILM CORPORATION (JP) | 2009-05-21 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| EP-1524262-A1 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2005-04-20 | — | — | EP | disclosed |
| EP-1280764-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2003-02-05 | — | — | EP | disclosed |
| US-20020177594-A1 | Inhibitors of histone deacetylase | ABBOTT LABORATORIES | 2002-11-28 | — | — | US | disclosed |
| US-20020115826-A1 | Inhibitors of histone deacetylase | 92229129 QUEBEC INC. (CA) | 2002-08-22 | — | — | US | disclosed |
| US-20020103192-A1 | Inhibitors of histone deacetylase | ABBOTT LABORATORIES | 2002-08-01 | — | — | US | disclosed |
| WO-2002046129-A2 | INHIBITORS OF HISTONE DEACETYLASE | ABBOTT LABORATORIES (US) | 2002-06-13 | — | — | WO | disclosed |
| WO-2001070675-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-09-27 | — | — | WO | disclosed |
| US-5066658-A | Enzyme Inhibitors; Bronchodilators; Antiinflammatory Agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103192-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC4 | HDAC3 6/4885HDAC4 3/4885HDAC1 1/4885 |
| US-20020177594-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC11, HDAC3 | HDAC3 3/4885HDAC4 10/4885HDAC1 1/4885 |
| US-20020115826-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC4 8/4885HDAC1 1/4885 |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC4 8/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.