Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 16/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385496 | 0.88 | KDR (0.50) | KDRFGFR3 | |
| SCHEMBL3382543 | 0.88 | KDR (0.56) | KDRFGFR3 | |
| SCHEMBL3383984 | 0.87 | KDR (0.68) | KDRFGFR3 | |
| SCHEMBL3385219 | 0.87 | KDR (0.53) | KDRFGFR3 | |
| SCHEMBL3380720 | 0.84 | KDR (0.58) | KDRFGFR3 | |
| SCHEMBL3381829 | 0.83 | KDR (0.51) | KDRFGFR3 | |
| SCHEMBL3385818 | 0.82 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3383482 | 0.81 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3186484 | 0.81 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385534 | 0.81 | KDR (0.50) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |