Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.50 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385352 | 0.91 | WNT3A (0.49) | KDRFGFR3RIOK2WNT3ARET | |
| SCHEMBL3385413 | 0.89 | RORC (0.48) | KDRFGFR3RIOK2WNT3ARET | |
| SCHEMBL3385818 | 0.88 | KDR (0.49) | KDRFGFR3RIOK2 | |
| SCHEMBL3417117 | 0.88 | WNT3A (0.49) | KDRFGFR3WNT3ACYP2D6PSEN1 | |
| SCHEMBL3381773 | 0.88 | KDR (0.55) | KDRFGFR3 | |
| SCHEMBL3186484 | 0.88 | KDR (0.49) | KDRFGFR3RIOK2 | |
| SCHEMBL3383482 | 0.88 | KDR (0.49) | KDRFGFR3RIOK2 | |
| SCHEMBL3195980 | 0.87 | RET (0.60) | KDRFGFR3RETMEN1KMT2A | |
| SCHEMBL3385476 | 0.86 | KDR (0.49) | KDRFGFR3RETNTRK1GSK3B | |
| SCHEMBL3382543 | 0.86 | KDR (0.56) | KDRFGFR3NTRK1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |