SCHEMBL338178

SCHEMBL338178

Cc1ccc(Br)c(Br)c1Br

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
CYP1A2 P05177 1/20 0.32
TSHR P16473 1/20 0.30
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31668870 0.87 ALDH1A1 (0.42) ALDH1A1CYP1A2TSHRACHE
SCHEMBL819186 0.87 ALDH1A1 (0.42) ALDH1A1CYP1A2TSHRACHE
SCHEMBL29646281 0.79 CYP2A6 (0.39) ALDH1A1
SCHEMBL358557 0.79 CYP2A6 (0.39) ALDH1A1
SCHEMBL30499370 0.79 ALDH1A1 (0.39) ALDH1A1CYP1A2
SCHEMBL3396598 0.79 ALDH1A1 (0.39) ALDH1A1CYP1A2
SCHEMBL1248015 0.79 NCEH1 (0.39) ALDH1A1CYP1A2TSHR
SCHEMBL30555886 0.75 CYP2A6 (0.36) ALDH1A1
SCHEMBL30555943 0.75 CYP2A6 (0.36) ALDH1A1
Methane SCHEMBL28608338 0.75 CYP2A6 (0.36) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0036352-B1 PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL BENZENES FROM THE CORRESPONDING TRICHLORO OR TRIBROMO METHYL BENZENES RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-06-01 EP claimed
EP-0036352-A1 Process for the preparation of trifluoromethyl benzenes from the corresponding trichloro or tribromo methyl benzenes RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1981-09-23 EP claimed
EP-3124490-A1 HIGH STABILITY POLYIONIC LIQUID SALTS Sigma-Aldrich Co. LLC (US) 2017-02-01 EP disclosed
EP-2114969-B1 HIGH STABILITY POLYIONIC LIQUID SALTS SIGMA ALDRICH CO LLC (US) 2016-06-29 EP disclosed
US-8481722-B2 High stability polyionic liquid salts SIGMA-ALDRICH CO. LLC (US) 2013-07-09 US disclosed
EP-1996653-B1 SURFACE MODIFIED PIGMENTS FOR INK-JET PRINTING INKS AND METHOD OF MAKING MODIFIED PIGMENTS HEWLETT PACKARD DEVELOPMENT CO (US) 2012-10-03 EP disclosed
US-8188139-B2 Heterocyclic-substituted phenyl methanones HOFFMAN-LA ROCHE INC. (US) 2012-05-29 US disclosed
US-20120083603-A1 HIGH STABILITY POLYIONIC LIQUID SALTS SIGMA-ALDRICH CO. LLC (US) 2012-04-05 US disclosed
US-8097721-B2 polycationic or polyanionic molecules; use as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry (ESI-MS); thermal stability; tris(anion) such as tris(sulfonate) or tris(cation) groups such as imidazolium, pyrrolidinium, ammonium SIGMA-ALDRICH CO. LLC (US) 2012-01-17 US disclosed
EP-2084125-B1 AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY UNIV HAUTE ALSACE (FR) 2012-01-11 EP disclosed
CN-1931803-B Organic electroluminescent material and its application UNIV TSINGHUA 2010-12-15 CN disclosed
US-4329251-A Titanium trichloride catalytic component and method for homo- or co-polymerization of α-olefin TOYO STAUFFER CHEMICAL CO., LTD. (JP) 1982-05-11 US disclosed
EP-0045423-A1 Process for the alpha-halogenation of possibly substituted methyl aromatics BAYER AG (DE) 1982-02-10 EP disclosed
US-4315090-A Titanium trichloride catalytic component and method for homo- or co-polymerization of α-olefin TOYO STAUFFER CHEMICAL CO., LTD. (JP) 1982-02-09 US disclosed
EP-0036352-A1 Process for the preparation of trifluoromethyl benzenes from the corresponding trichloro or tribromo methyl benzenes RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1981-09-23 EP disclosed
EP-0036352-A1 Process for the preparation of trifluoromethyl benzenes from the corresponding trichloro or tribromo methyl benzenes RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1981-09-23 EP disclosed
US-4284525-A ORGANOALUMINUM COMPOUND, ETHER, SOLVENT, COOLING, MULTISTAGE TOYO STAUFFER CHEMICAL CO., LTD. (JP) 1981-08-18 US disclosed
EP-0030018-A2 Titanium trichloride catalytic component and method for homo- or co-polymerization of alpha-olefin TOYO STAUFFER CHEMICAL CO. LTD. (JP) 1981-06-10 EP disclosed
US-4251388-A Titanium trichloride catalytic component and method for homo- or co-polymerization of α-olefin TOYO STAUFFER CHEMICAL CO., LTD. (JP) 1981-02-17 US disclosed
EP-0021822-A1 Titanium trichloride catalytic component and method for homo- or co-polymerization of alpha-olefins TOYO STAUFFER CHEMICAL CO. LTD. (JP) 1981-01-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120083603-A1 HIGH STABILITY POLYIONIC LIQUID SALTS PUF60, POLI, PARG ALDH1A1 4720/4885CYP1A2 4876/4885TSHR 4659/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.