⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381914 | 1.00 | — | — | |
| SCHEMBL11652612 | 0.75 | — | — | |
| SCHEMBL7159922 | 0.72 | ALDH1A1 (0.32) | — | |
| SCHEMBL9589273 | 0.72 | ALDH1A1 (0.32) | — | |
| SCHEMBL7159918 | 0.72 | ALDH1A1 (0.32) | — | |
| SCHEMBL9158212 | 0.70 | — | — | |
| SCHEMBL21920980 | 0.70 | — | — | |
| SCHEMBL9158210 | 0.70 | — | — | |
| SCHEMBL160478 | 0.69 | — | — | |
| SCHEMBL11651178 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280764-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2010-11-24 | — | — | EP | disclosed |
| EP-2093292-A2 | Inhibition of specific histone deacetylase isoforms | Methylgene, Inc. (CA) | 2009-08-26 | — | — | EP | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| EP-1524262-A1 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2005-04-20 | — | — | EP | disclosed |
| US-20040266718-A1 | Inhibition of specific histone deacetylase isoforms | LI ZUOMEI (CA) | 2004-12-30 | — | — | US | disclosed |
| EP-1438404-A2 | INHIBITION OF SPECIFIC HISTONE DEACETYLASE ISOFORMS | Methylgene, Inc. (CA) | 2004-07-21 | — | — | EP | disclosed |
| US-20030152557-A1 | Methods for inhibiting histone deacetylase-4 | METHYLGENE, INC. (CA) | 2003-08-14 | — | — | US | disclosed |
| US-20030148970-A1 | Methods for specifically inhibiting histone deacetylase-4 | METHYLGENE, INC. (CA) | 2003-08-07 | — | — | US | disclosed |
| EP-1280764-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2003-02-05 | — | — | EP | disclosed |
| WO-2003006652-A2 | INHIBITION OF SPECIFIC HISTONE DEACETYLASE ISOFORMS | METHYLGENE, INC. (CA) | 2003-01-23 | — | — | WO | disclosed |
| US-20020115826-A1 | Inhibitors of histone deacetylase | 92229129 QUEBEC INC. (CA) | 2002-08-22 | — | — | US | disclosed |
| US-20020061860-A1 | Antisense oligonucleotide inhibition of specific histone deacetylase isoforms | METHYLGENE, INC. (CA) | 2002-05-23 | — | — | US | disclosed |
| WO-2001070675-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-09-27 | — | — | WO | disclosed |