Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 8/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 8/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 8/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 8/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383043 | 1.00 | KMT2A (0.62) | KMT2ABCHEMAOATSHRGRIN2D | |
| SCHEMBL8200714 | 0.91 | KMT2A (0.58) | KMT2ABCHEMAOATSHRGRIN2D | |
| Hydrochloric Acid SCHEMBL422740 | 0.90 | KMT2A (0.57) | KMT2ABCHEMAOATSHRGRIN2D | |
| Hydrochloric Acid SCHEMBL6478440 | 0.87 | BCHE (0.57) | KMT2ABCHEMAOATSHRGRIN2D | |
| SCHEMBL7715339 | 0.84 | BCHE (0.60) | KMT2ABCHEMAOATSHRGRIN2D | |
| Water SCHEMBL6489575 | 0.83 | BCHE (0.58) | KMT2ABCHEMAOATSHRGRIN2D | |
| SCHEMBL8469394 | 0.83 | KMT2A (0.60) | KMT2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8202805 | 0.82 | BCHE (0.55) | KMT2ABCHEMAOATSHRGRIN2D | |
| Hydrochloric Acid SCHEMBL420910 | 0.81 | BCHE (0.54) | KMT2ABCHEMAOATSHRGRIN2D | |
| SCHEMBL12394541 | 0.80 | BCHE (0.55) | KMT2ABCHEMAOATSHRGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013007371-A2 | KINETIC RESOLUTION OF CHIRAL AMINES | ETH ZURICH (CH) | 2013-01-17 | — | — | WO | disclosed |
| EP-1638970-B1 | PYRID (2, 1-A) - ISOQUINOLINE DERIVATIVES AS DPP-IV INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| US-7122555-B2 | Pyrido [2,1-a] isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1638970-A1 | PYRID (2, 1-A) - ISOQUINOLINE DERIVATIVES AS DPP-IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000848-A1 | PYRIDO` 2, 1-A - ISOQUINOLINE DERIVATIVES AS DPP-IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-06 | — | — | WO | disclosed |
| US-20040259903-A1 | Pyrido [2,1-a] isoquinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259903-A1 | Pyrido [2,1-a] isoquinoline derivatives | DPP4, SLC5A1, DPP7 | KMT2A 2209/4885BCHE 1800/4885MAOA 2397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.