Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 17/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381193 | 0.99 | CNR2 (0.50) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3380173 | 0.92 | CNR2 (0.53) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3382370 | 0.90 | CNR2 (0.56) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3379226 | 0.89 | CNR2 (0.57) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3380875 | 0.87 | CNR2 (0.57) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3379095 | 0.87 | CNR2 (0.53) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3379227 | 0.86 | CNR2 (0.52) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3383193 | 0.85 | CNR2 (0.53) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3378890 | 0.84 | CNR2 (0.68) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL3382325 | 0.84 | CNR2 (0.62) | CNR2CYP2C19CYP3A4CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878725-B1 | Pyrimidine derivatives and their use as CB2 modulators | GLAXO GROUP LTD (GB) | 2010-11-24 | — | — | EP | claimed |