Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 1/20 | 0.60 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.60 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.60 |
| ▸ | ANO1 | Q5XXA6 | 10/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705871 | 0.84 | ANO1 (0.50) | KCNJ6KCNJ5KCNJ3ANO1RET | |
| SCHEMBL3195230 | 0.84 | ANO1 (0.46) | KCNJ6KCNJ5KCNJ3ANO1MAPT | |
| SCHEMBL3383444 | 0.83 | ANO1 (0.55) | ANO1MAPTMEN1KMT2AGAA | |
| SCHEMBL27705870 | 0.83 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3ANO1MAPT | |
| SCHEMBL3193770 | 0.79 | ANO1 (0.44) | ANO1 | |
| SCHEMBL2301405 | 0.79 | KMT2A (0.56) | HDAC3HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL16046822 | 0.75 | KMT2A (0.61) | KCNJ5KCNJ3MAPTMEN1KMT2A | |
| SCHEMBL4966812 | 0.75 | AAK1 (0.44) | ANO1KDRGAASMN1; SMN2 | |
| SCHEMBL19729064 | 0.74 | KCNJ6 (0.67) | KCNJ6KCNJ5KCNJ3NLRP3MAPT | |
| SCHEMBL16045905 | 0.74 | RET (0.58) | KCNJ5KCNJ3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |