Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383409 | 0.83 | KCNJ6 (0.60) | ANO1KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL16046822 | 0.77 | KMT2A (0.61) | LMNAKMT2AALDH1A1MEN1ALOX15 | |
| SCHEMBL27705871 | 0.75 | ANO1 (0.50) | ANO1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3195230 | 0.75 | ANO1 (0.46) | ANO1LMNAKMT2AMEN1HTT | |
| SCHEMBL14720058 | 0.75 | P2RX7 (0.51) | POLBNPC1CYP2C19MAPT | |
| SCHEMBL16045905 | 0.73 | RET (0.58) | LMNAKMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL8444 | 0.73 | DGAT1 (0.46) | KMT2AMEN1HSD17B10CYP1A2MAPK1 | |
| SCHEMBL16046621 | 0.73 | RET (0.47) | KMT2AALDH1A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL19976712 | 0.72 | KMT2A (0.63) | LMNAKMT2AALDH1A1MEN1ESR1 | |
| SCHEMBL5820518 | 0.72 | L3MBTL1 (0.73) | LMNAKMT2AALDH1A1MEN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |