Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 13/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3189267 | 0.90 | KDR (0.45) | KDRFGFR3 | |
| SCHEMBL3382504 | 0.88 | KDR (0.47) | KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3383762 | 0.88 | KDR (0.45) | KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3202028 | 0.86 | KDR (0.41) | KDRFGFR3 | |
| SCHEMBL3385300 | 0.85 | KDR (0.44) | KDRFGFR3PIK3CAMTORNEK2 | |
| SCHEMBL3385381 | 0.83 | KDR (0.42) | KDRFGFR3PIK3CAMTORNEK2 | |
| SCHEMBL3383110 | 0.82 | RET (0.48) | KDRFGFR3 | |
| SCHEMBL3381852 | 0.82 | KDR (0.56) | KDRFGFR3 | |
| SCHEMBL3381930 | 0.82 | KDR (0.39) | KDRFGFR3 | |
| SCHEMBL3385818 | 0.82 | KDR (0.49) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |