Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 14/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386163 | 0.93 | WNT3A (0.42) | KDRFGFR3WNT3A | |
| SCHEMBL3383499 | 0.93 | KDR (0.46) | KDRFGFR3WNT3AFLT3PIK3CA | |
| SCHEMBL3385818 | 0.93 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385477 | 0.91 | FGFR3 (0.41) | KDRFGFR3 | |
| SCHEMBL3384812 | 0.90 | KDR (0.45) | KDRFGFR3WNT3AFLT3PIK3CA | |
| SCHEMBL3189267 | 0.90 | KDR (0.45) | KDRFGFR3WNT3A | |
| SCHEMBL3381930 | 0.89 | KDR (0.39) | KDRFGFR3 | |
| SCHEMBL3383240 | 0.88 | FGFR3 (0.49) | KDRFGFR3WNT3A | |
| SCHEMBL3381852 | 0.88 | KDR (0.56) | KDRFGFR3 | |
| SCHEMBL3385600 | 0.88 | KDR (0.46) | KDRFGFR3NTRK1WNT3AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |