Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 12/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385345 | 0.91 | RET (0.60) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3386505 | 0.85 | RET (0.65) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3176763 | 0.85 | RET (0.53) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3188885 | 0.85 | RET (0.58) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3383110 | 0.82 | RET (0.48) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3186841 | 0.82 | RET (0.53) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3185001 | 0.81 | RET (0.52) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3178793 | 0.80 | RET (0.51) | RETNTRK1CSF1RKDRKCNH2 | |
| SCHEMBL3385534 | 0.79 | KDR (0.50) | RETKDRFLT3 | |
| SCHEMBL3383013 | 0.79 | RET (0.48) | RETNTRK1CSF1RKDRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |