Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 9/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381104 | 0.92 | KDR (0.55) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3186841 | 0.90 | RET (0.53) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3385345 | 0.89 | RET (0.60) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3385275 | 0.89 | KDR (0.51) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3383112 | 0.88 | RET (0.53) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3178793 | 0.88 | RET (0.51) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3383492 | 0.87 | FLT3 (0.50) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3383547 | 0.85 | RET (0.56) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3176763 | 0.85 | RET (0.53) | RETCSF1RNTRK1KDRKCNH2 | |
| SCHEMBL3188885 | 0.85 | RET (0.58) | RETCSF1RNTRK1KDRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |