Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176784 | 0.87 | KDR (0.47) | KDRFGFR3FLT3 | |
| SCHEMBL3183935 | 0.87 | KDR (0.40) | KDRFGFR3FLT3NAMPTHDAC1 | |
| SCHEMBL3188717 | 0.85 | KDR (0.47) | KDRFGFR3FLT3NAMPTHDAC1 | |
| SCHEMBL3190565 | 0.83 | KDR (0.48) | KDRFGFR3HDAC1 | |
| SCHEMBL3197804 | 0.82 | KDR (0.55) | KDRFGFR3 | |
| SCHEMBL506891 | 0.81 | CYP17A1 (0.61) | CYP17A1NAMPTHDAC1 | |
| SCHEMBL3384408 | 0.79 | KDR (0.50) | KDRFGFR3FLT3 | |
| SCHEMBL3380736 | 0.79 | KDR (0.50) | KDRFGFR3FLT3 | |
| SCHEMBL3385883 | 0.79 | KDR (0.50) | KDRFGFR3 | |
| SCHEMBL3385534 | 0.79 | KDR (0.50) | KDRFGFR3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |