Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383429 | 0.90 | FLT3 (0.48) | KDRFGFR3MAPK14MAPK11ERBB2 | |
| SCHEMBL3381138 | 0.90 | KDR (0.42) | KDRFGFR3MAPK14MAPK11ERBB2 | |
| SCHEMBL3385668 | 0.88 | RET (0.47) | KDRFGFR3MAPK14MAPK11ERBB2 | |
| SCHEMBL3382710 | 0.88 | MAPK14 (0.60) | KDRFGFR3MAPK14MAPK11ERBB2 | |
| SCHEMBL3385035 | 0.84 | KDR (0.49) | KDRFGFR3MAPK14MAPK13RAF1 | |
| SCHEMBL3383685 | 0.84 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385811 | 0.84 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3176929 | 0.82 | FLT3 (0.45) | KDRFGFR3MAPK14MAPK11MAPK13 | |
| SCHEMBL3385534 | 0.82 | KDR (0.50) | KDRFGFR3MAPK14MAPK13RAF1 | |
| SCHEMBL3384408 | 0.82 | KDR (0.50) | KDRFGFR3RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |