Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 17/20 | 0.48 |
| ▸ | KDR | P35968 | 17/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384511 | 0.86 | KDR (0.55) | FGFR3KDR | |
| SCHEMBL3384065 | 0.79 | KDR (0.52) | FGFR3KDR | |
| SCHEMBL3381138 | 0.77 | KDR (0.42) | FGFR3KDR | |
| SCHEMBL11929274 | 0.76 | FGFR3 (0.79) | FGFR3KDR | |
| SCHEMBL3383984 | 0.75 | KDR (0.68) | FGFR3KDR | |
| SCHEMBL3380720 | 0.75 | KDR (0.58) | FGFR3KDR | |
| SCHEMBL3385738 | 0.74 | FLT3 (0.49) | FGFR3KDR | |
| SCHEMBL27705887 | 0.74 | FGFR3 (0.54) | FGFR3KDR | |
| SCHEMBL1790420 | 0.74 | CA1 (0.67) | CA1CA2CA7CA9KDR | |
| SCHEMBL3177632 | 0.74 | FGFR3 (0.56) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |