Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385738 | 0.89 | FLT3 (0.49) | KDRFGFR3MEN1KMT2AMAPT | |
| SCHEMBL13483163 | 0.88 | FGFR3 (0.50) | KDRFGFR3BLM | |
| SCHEMBL3195980 | 0.85 | RET (0.60) | KDRFGFR3MEN1KMT2AMAPT | |
| SCHEMBL3385496 | 0.80 | KDR (0.50) | KDRFGFR3MEN1KMT2A | |
| SCHEMBL3385476 | 0.79 | KDR (0.49) | KDRFGFR3FLT1CSF1R | |
| SCHEMBL3384064 | 0.79 | CA1 (0.49) | KDRFGFR3 | |
| SCHEMBL3382028 | 0.78 | KDR (0.58) | KDRFGFR3 | |
| SCHEMBL3417117 | 0.78 | WNT3A (0.49) | KDRFGFR3 | |
| SCHEMBL3381109 | 0.77 | RET (0.56) | KDRFGFR3 | |
| SCHEMBL3384190 | 0.76 | KDR (0.62) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |