SCHEMBL3384133

SCHEMBL3384133

CC(Cl)c1cccc([N+](=O)[O-])c1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.57
LMNA P02545 2/20 0.57
KMT2A Q03164 2/20 0.54
MEN1 O00255 1/20 0.54
HPGD P15428 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
ALDH1A1 P00352 5/20 0.53
ACHE P22303 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
ACP3 P15309 1/20 0.51
MAPT P10636 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
ALOX15 P16050 1/20 0.48
HSP90AA1 P07900 1/20 0.47
HTT P42858 2/20 0.47
GAA P10253 1/20 0.46
CES2 O00748 1/20 0.46
CES1 P23141 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9026172 0.87 TSHR (0.59) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL254876 0.85 TSHR (0.61) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL3642758 0.85 TSHR (0.61) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL7788899 0.82 TSHR (0.53) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL27965075 0.82 TSHR (0.53) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL6359586 0.81 TSHR (0.57) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL2433538 0.81 TSHR (0.57) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL2545597 0.81 MEN1 (0.61) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL10654030 0.81 TSHR (0.57) TSHRLMNAKMT2AMEN1HPGD
SCHEMBL2540712 0.81 TSHR (0.57) TSHRLMNAKMT2AMEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115066428-B Boric acid derivatives 首药控股(北京)股份有限公司 2025-06-13 CN disclosed
CN-105980381-A Substituted uracils and use thereof 拜耳医药股份有限公司 2016-09-28 CN disclosed
US-20100056524-A1 Compound MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-03-04 US disclosed
US-20100056524-A1 Compound MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-03-04 US disclosed
WO-2009122180-A1 PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES MEDICAL RESEARCH COUNCIL (GB) 2009-10-08 WO disclosed
WO-2009122180-A1 PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES MEDICAL RESEARCH COUNCIL (GB) 2009-10-08 WO disclosed
CN-1028864-C Macrolide compounds and their preparation SANKYO CO (JP) 1995-06-14 CN disclosed
CN-1022834-C Macrolide compounds, their preparation and their use SANKYO CO (JP) 1993-11-24 CN disclosed
CN-1071430-A Macrolide bonded preparation method SANKYO CO (JP) 1993-04-28 CN disclosed
CN-87103559-A Macrolide compounds, their production and use 1988-01-27 CN disclosed
US-4436751-A Nitrobenzyl monates antibacterial compounds BEECHAM GROUP LIMITED (GB) 1984-03-13 US disclosed
US-4348223-A FOR PREEMERGENT AND POSTEMERGENT APPLICATION PPG INDUSTRIES, INC. (US) 1982-09-07 US disclosed
EP-0055616-A1 Antibacterial compounds BEECHAM GROUP PLC (GB) 1982-07-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056524-A1 Compound NR3C2, NR3C1, NR2E3 TSHR 133/4885LMNA 4683/4885KMT2A 3200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.