Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.37 |
| ▸ | CDK2 | P24941 | 10/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 3/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3196988 | 0.89 | FGFR3 (0.35) | FGFR3KDRCTSCSIK1SIK2 | |
| SCHEMBL3196972 | 0.89 | FGFR3 (0.35) | FGFR3KDRCTSCSIK1SIK2 | |
| SCHEMBL3383608 | 0.88 | SMN1; SMN2 (0.34) | FGFR3KDRCTSCSMN1; SMN2SIK1 | |
| SCHEMBL3186871 | 0.86 | FGFR3 (0.33) | FGFR3KDRCTSCSIK1SIK2 | |
| SCHEMBL3186881 | 0.86 | FGFR3 (0.33) | FGFR3KDRCTSCSIK1SIK2 | |
| SCHEMBL3383109 | 0.84 | KDR (0.35) | FGFR3KDRCTSC | |
| SCHEMBL3381810 | 0.84 | CCNE1 (0.48) | CCNE1CDK2CDK5CDK5R1FGFR3 | |
| SCHEMBL3195990 | 0.83 | KDR (0.42) | CCNE1CDK2CDK5CDK5R1FGFR3 | |
| SCHEMBL3188986 | 0.82 | RIPK3 (0.38) | FGFR3KDRSIK1SIK2SIK3 | |
| SCHEMBL3186146 | 0.82 | FGFR3 (0.36) | FGFR3KDRCTSCSIK1SIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |