Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.33 |
| ▸ | KDR | P35968 | 9/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | SIK1 | P57059 | 4/20 | 0.32 |
| ▸ | SIK2 | Q9H0K1 | 4/20 | 0.32 |
| ▸ | SIK3 | Q9Y2K2 | 4/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380785 | 0.91 | FGFR3 (0.36) | SMN1; SMN2FGFR3KDR | |
| SCHEMBL3384486 | 0.88 | CCNE1 (0.37) | SMN1; SMN2FGFR3KDRPDGFRASIK1 | |
| SCHEMBL3196988 | 0.88 | FGFR3 (0.35) | FGFR3KDRPSEN1PSEN2APH1B | |
| SCHEMBL3196972 | 0.88 | FGFR3 (0.35) | FGFR3KDRPSEN1PSEN2APH1B | |
| SCHEMBL3186881 | 0.88 | FGFR3 (0.33) | FGFR3KDRPDGFRASIK1SIK2 | |
| SCHEMBL3186871 | 0.88 | FGFR3 (0.33) | FGFR3KDRPDGFRASIK1SIK2 | |
| SCHEMBL3382693 | 0.85 | WNT3A (0.41) | SMN1; SMN2FGFR3KDR | |
| SCHEMBL3379579 | 0.84 | KDR (0.43) | SMN1; SMN2FGFR3KDR | |
| SCHEMBL3383109 | 0.84 | KDR (0.35) | FGFR3KDRCTSC | |
| SCHEMBL13002537 | 0.83 | KDR (0.34) | FGFR3KDRCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |