Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.54 |
| ▸ | RAF1 | P04049 | 9/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845037 | 0.90 | BRAF (0.64) | BRAFRAF1CSF1RNTRK1ABL1 | |
| SCHEMBL3384170 | 0.89 | BRAF (0.53) | BRAFRAF1CSF1RNTRK1NTRK2 | |
| SCHEMBL3384692 | 0.86 | BRAF (0.54) | BRAFRAF1CSF1RABL1BCR | |
| SCHEMBL3384315 | 0.82 | BRAF (0.64) | BRAFRAF1CSF1RNTRK1ABL1 | |
| SCHEMBL3382786 | 0.82 | NTRK1 (0.56) | CSF1RNTRK1NTRK2ABL1BCR | |
| SCHEMBL3387590 | 0.79 | BRAF (0.58) | BRAFRAF1ABL1BCRFGFR1 | |
| SCHEMBL8739745 | 0.78 | FGFR1 (0.41) | BRAFRAF1FGFR1DDR2AAK1 | |
| SCHEMBL3383253 | 0.75 | NTRK1 (0.59) | CSF1RNTRK1NTRK2DDR2 | |
| SCHEMBL3384952 | 0.74 | NR2E1 (0.56) | BRAFRAF1CSF1RABL1BCR | |
| SCHEMBL13459819 | 0.71 | CSF1R (0.50) | BRAFRAF1CSF1RNTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102239150-A | Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient | KOREA INST SCI & TECH | 2011-11-09 | — | — | CN | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| CN-102239150-A | Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient | KOREA INST SCI & TECH | 2011-11-09 | — | — | CN | disclosed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |