Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387854 | 0.93 | ROCK2 (0.60) | ROCK2CLK4USP2LMNACYP1A2 | |
| SCHEMBL13362623 | 0.83 | ROCK2 (0.42) | ROCK2CLK4USP2LMNACYP1A2 | |
| SCHEMBL13362739 | 0.80 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL3386714 | 0.80 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL13362854 | 0.80 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL3385424 | 0.79 | ROCK2 (0.82) | ROCK2 | |
| SCHEMBL13362852 | 0.77 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL3388227 | 0.76 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL3387837 | 0.76 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL3382939 | 0.76 | ROCK2 (0.83) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |